abstract：:Cardiometabolic risk factors are sorely underreported after spinal cord injury (SCI), despite the high prevalence of metabolic disorders and cardiovascular mortality in this population. Body-composition analysis and serum-lipid profiling are two assessments that are beginning to be more widely used to document metabol...

journal_title：Journal of neurotrauma

authors： Inskip J,Plunet W,Ramer L,Ramsey JB,Yung A,Kozlowski P,Ramer M,Krassioukov A

更新日期：2010-01-01 00:00:00

abstract：:The aim of this systematic review was to critically evaluate the evidence on interventions for depression following traumatic brain injury (TBI) and provide recommendations for clinical practice and future research. We reviewed pharmacological, other biological, psychotherapeutic, and rehabilitation interventions for ...

journal_title：Journal of neurotrauma

authors： Fann JR,Hart T,Schomer KG

更新日期：2009-12-01 00:00:00

abstract：:This study aimed to investigate the cortical motor excitability characteristics in diffuse axonal injury (DAI) due to severe traumatic brain injury (TBI). A variety of excitatory and inhibitory transcranial magnetic stimulation (TMS) paradigms were applied to primary motor cortices of 17 patients and 11 healthy contro...

journal_title：Journal of neurotrauma

authors： Bernabeu M,Demirtas-Tatlidede A,Opisso E,Lopez R,Tormos JM,Pascual-Leone A

更新日期：2009-12-01 00:00:00

abstract：:Bone marrow stromal cells (BMSC) transplanted into the contused spinal cord may support repair by improving tissue sparing. We injected allogeneic BMSC into the moderately contused adult rat thoracic spinal cord at 15 min (acute) and at 3, 7, and 21 days (delayed) post-injury and quantified tissue sparing and BMSC sur...

journal_title：Journal of neurotrauma

authors： Nandoe Tewarie RD,Hurtado A,Ritfeld GJ,Rahiem ST,Wendell DF,Barroso MM,Grotenhuis JA,Oudega M

更新日期：2009-12-01 00:00:00

abstract：:Recent calls have been made for the inclusion of health-related quality of life (HRQoL) in traumatic brain injury studies. This study reports the impact of TBI on traditional measures (general health, depression, social isolation, labor force participation), self-assessed health function status using the SF-36 version...

journal_title：Journal of neurotrauma

authors： Hawthorne G,Gruen RL,Kaye AH

更新日期：2009-10-01 00:00:00

abstract：:Neuropsychological studies in electrical injury patients have reported deficits in attention, learning, and working memory, but the neural substrates of these deficits remain poorly characterized. In this study we sought to examine whether electrical injury subjects demonstrate abnormal patterns of brain activation du...

journal_title：Journal of neurotrauma

authors： Ramati A,Pliskin NH,Keedy S,Erwin RJ,Fink JW,Bodnar EN,Lee RC,Cooper MA,Kelley K,Sweeney JA

更新日期：2009-10-01 00:00:00

abstract：:Acute pain is a common symptom experienced after spinal cord injury (SCI). The presence of this pain calls for treatment with analgesics, such as buprenorphine. However, there are concerns that the drug may exert other effects besides alleviation of pain. Among those reported are in vitro changes in gene expression, a...

journal_title：Journal of neurotrauma

authors： Santiago JM,Rosas O,Torrado AI,González MM,Kalyan-Masih PO,Miranda JD

更新日期：2009-10-01 00:00:00

abstract：:Restraint stress (RS) protects auditory function against acoustic trauma by activating glucocorticoid receptors (GR) in the cochlea. In a search for the signaling pathways downstream to GR that may be involved in RS-induced protection we report here (1) a downregulation of phosphorylated extracellular signal-regulated...

journal_title：Journal of neurotrauma

authors： Meltser I,Tahera Y,Canlon B

更新日期：2009-10-01 00:00:00

abstract：:Aging may be an important factor affecting brain injury by intracerebral hemorrhage (ICH). In the present study, we investigated the responses of glial cells and monocytes to intracerebral hemorrhage in normal and aged rats. ICH was induced by microinjecting autologous whole blood (15 microL) into the striatum of youn...

journal_title：Journal of neurotrauma

authors： Lee JC,Cho GS,Choi BO,Kim HC,Kim WK

更新日期：2009-09-01 00:00:00

abstract：:Lesions in specific areas of the rat motor cortex generate deficits related to fine movement performance affecting the forelimb. We have previously shown that transplants of embryonic frontal cortex ameliorate these motor deficits. Amelioration has been associated with a functional integration of the transplant due to...

journal_title：Journal of neurotrauma

authors： Santos-Torres J,Heredia M,Riolobos AS,Jiménez-Díaz L,Gómez-Bautista V,de la Fuente A,Criado JM,Navarro-López J,Yajeya J

更新日期：2009-09-01 00:00:00

abstract：:Despite the shift in demographics of spinal cord injury (SCI) due to an aging population, relatively little has been reported regarding the effect of age on outcomes after SCI. This study examines the potential confounding effect of co-morbidities on the age-related differences in the hospital mortality following acut...

journal_title：Journal of neurotrauma

authors： Furlan JC,Kattail D,Fehlings MG

更新日期：2009-08-01 00:00:00

abstract：:Brain injury after high-level blast has been established both clinically and experimentally. Less is known about the effects on the brain of exposure to low to moderate blast levels, such as those encountered by military personnel during the firing of weapons. This study investigates if exposure to occupational levels...

journal_title：Journal of neurotrauma

authors： Säljö A,Svensson B,Mayorga M,Hamberger A,Bolouri H

更新日期：2009-08-01 00:00:00

abstract：:Wars in Afghanistan and Iraq have resulted in thousands of military personnel suffering traumatic brain injury (TBI), including closed-head injuries. Of interest is whether these individuals and other TBI survivors are at increased risk for substance use disorder (SUD). While it has been well established that drug or ...

journal_title：Journal of neurotrauma

authors： Bjork JM,Grant SJ

更新日期：2009-07-01 00:00:00

abstract：:Previous studies from our laboratory have shown the neuroprotective potential of ketones after TBI in the juvenile brain. It is our premise that acutely after TBI, glucose may not be the optimum fuel and decreasing metabolism of glucose in the presence of an alternative substrate will improve cellular metabolism and r...

journal_title：Journal of neurotrauma

authors： Prins ML,Hovda DA

更新日期：2009-07-01 00:00:00

abstract：:Spinal cord injury (SCI) launches a complex cascade of events that leads to progressive damage and loss of function. Compromise of plasma membrane integrity due to the mechanical impact is an acute event that may contribute to cellular dysfunction. Therefore, the objective of this study was to better understand the ex...

journal_title：Journal of neurotrauma

authors： Simon CM,Sharif S,Tan RP,LaPlaca MC

更新日期：2009-04-01 00:00:00

abstract：:Improving survival and brain function after initial resuscitation from cardiac arrest remains a critical challenge with few therapeutic options. The publication of several randomized controlled trials supporting the use of therapeutic hypothermia in cardiac arrest survivors has provided a remarkable opportunity to red...

journal_title：Journal of neurotrauma

authors： Sugerman NT,Abella BS

更新日期：2009-03-01 00:00:00

abstract：:Formation of a glial scar is one of the major obstacles to axonal growth after injury to the adult CNS. In this study, we have addressed this issue by focusing on reactive astrocytes in a mouse model of spinal cord injury (SCI). First, we attempted to identify profile changes in the expression of astrocytic gliosis 10...

journal_title：Journal of neurotrauma

authors： Ito M,Natsume A,Takeuchi H,Shimato S,Ohno M,Wakabayashi T,Yoshida J

更新日期：2009-01-01 00:00:00

abstract：:Mood disturbances, including depression and anxiety disorders, are common and disabling long-term sequelae of traumatic brain injury (TBI). These psychiatric conditions have generally been considered psychosocial consequences of the trauma, but neurobiological alterations and causes have also been implicated. Using a ...

journal_title：Journal of neurotrauma

authors： Jones NC,Cardamone L,Williams JP,Salzberg MR,Myers D,O'Brien TJ

更新日期：2008-11-01 00:00:00

abstract：:The detection of neuron-specific proteins in blood might allow quantification of the degree of neuropathology in experimental and clinical contexts. We have been studying a novel blood biomarker of axonal injury, the heavily phosphorylated axonal form of the high molecular weight neurofilament subunit NF-H (pNF-H). We...

journal_title：Journal of neurotrauma

authors： Anderson KJ,Scheff SW,Miller KM,Roberts KN,Gilmer LK,Yang C,Shaw G

更新日期：2008-09-01 00:00:00

abstract：:The canine double hemorrhage model is an established model to study cerebral vasospasm, the late sequelae of subarachnoid hemorrhage (SAH). The present study uses magnetic resonance imaging (MRI) to examine the recently reported early brain injury after SAH. Double hemorrhage SAH modeling was obtained by injecting 0.5...

journal_title：Journal of neurotrauma

authors： Jadhav V,Sugawara T,Zhang J,Jacobson P,Obenaus A

更新日期：2008-09-01 00:00:00

abstract：:Acute changes in cerebral perfusion and metabolism after subarachnoid hemorrhage (SAH) have been shown to contribute significantly to acute brain injury. The purpose of this study was to examine the effects of moderate hypothermia on the acute changes after massive experimental SAH as evaluated by diffusion-weighted i...

journal_title：Journal of neurotrauma

authors： Schubert GA,Poli S,Schilling L,Heiland S,Thomé C

更新日期：2008-07-01 00:00:00

abstract：:Traumatic brain injury (TBI) results in an accumulation of edema and loss of brain tissue. Progesterone (PROG) has been reported to reduce edema and cortical tissue loss in a bilateral prefrontal cortex injury. This study tests the hypothesis that PROG is neuroprotective following a unilateral parietal cortical contus...

journal_title：Journal of neurotrauma

authors： Gilmer LK,Roberts KN,Scheff SW

更新日期：2008-06-01 00:00:00

abstract：:ABSTRACT Preliminary evidence has shown that intracerebral hemorrhages, either spontaneous (sICH) or traumatic (tICH) often expand over time. An association between hemorrhage expansion and clinical outcomes has been described for sICH. The intent of this prospective, observational study was to characterize the tempor...

journal_title：Journal of neurotrauma

authors： Narayan RK,Maas AI,Servadei F,Skolnick BE,Tillinger MN,Marshall LF,Traumatic Intracerebral Hemorrhage Study Group.

更新日期：2008-06-01 00:00:00

abstract：:Following crush injury to the facial nerve in Syrian hamsters, treatment with androgens enhances axonal regeneration rates and decreases time to recovery. It has been demonstrated in vitro that the ability of androgen to enhance neurite outgrowth in motoneurons is dependent on neuritin-a protein that is involved in th...

journal_title：Journal of neurotrauma

authors： Fargo KN,Alexander TD,Tanzer L,Poletti A,Jones KJ

更新日期：2008-05-01 00:00:00

abstract：:Inducible nitric oxide synthase (iNOS) has been suggested to play a complex role in the response to central nervous system insults such as traumatic brain injury (TBI) and cerebral ischemia. In the current study, we quantified maps of regional cerebral blood flow (CBF) using an arterial spin-labeling magnetic resonanc...

journal_title：Journal of neurotrauma

authors： Foley LM,Hitchens TK,Melick JA,Bayir H,Ho C,Kochanek PM

更新日期：2008-04-01 00:00:00

abstract：:The goal of this investigation was to develop a method to study the neurophysiological integrity of the central motor tract using motor evoked potentials in the awake rat and assess the effects of different anesthetics in this model. Rats were implanted with six subcutaneous electrodes (pediatric myocardial pacing lea...

journal_title：Journal of neurotrauma

authors： Oria M,Chatauret N,Raguer N,Córdoba J

更新日期：2008-03-01 00:00:00

abstract：:Noise exposure is known to induce cell death signaling in the cochlea. Since c-Jun N-terminal kinase (JNK) signaling is known to induce both cell survival and apoptosis, the present study focused on early changes (within 24 h) after impulse noise exposure, inquiring whether cell death is always related to phosphorylat...

journal_title：Journal of neurotrauma

authors： Murai N,Kirkegaard M,Järlebark L,Risling M,Suneson A,Ulfendahl M

更新日期：2008-01-01 00:00:00

abstract：:Predicting outcome after pediatric traumatic brain injury (TBI) is important for providing information to families and prescribing rehabilitation services. The study objective was to assess whether biomarkers concentrations obtained at the time of injury are associated with outcome. Serial serum concentrations of neur...

journal_title：Journal of neurotrauma

authors： Berger RP,Beers SR,Richichi R,Wiesman D,Adelson PD

更新日期：2007-12-01 00:00:00

abstract：:Coagulopathy is a common phenomenon in traumatic brain injury (TBI) and a major contributor to a poor outcome. Thrombocytopenia is a strong negative prognostic factor in TBI, but bleeding tendency can be present even with a normal platelet count. We investigated platelet function in patients with TBI by means of modif...

journal_title：Journal of neurotrauma

authors： Nekludov M,Bellander BM,Blombäck M,Wallen HN

更新日期：2007-11-01 00:00:00

abstract：:Accurate localization of cerebrospinal fluid (CSF) fistula in a patient with CSF rhinorrhea is challenging and often involves multiple imaging studies with associated expense and patient discomfort. Intrathecal contrast-enhanced computed tomography (CT) and unenhanced magnetic resonance (MR) cisternography using const...

journal_title：Journal of neurotrauma

authors： Goel G,Ravishankar S,Jayakumar PN,Vasudev MK,Shivshankar JJ,Rose D,Anandh B

更新日期：2007-10-01 00:00:00

abstract：:Anesthetics can either promote or inhibit the development of neurogenic pulmonary edema (NPE) after central nervous system (CNS) injury. The influence of isoflurane was examined in male Wistar rats using 1.5%, 2%, 2.5%, 3%, 4%, or 5% isoflurane in air. Epidural balloon compression of the thoracic spinal cord was perfo...

journal_title：Journal of neurotrauma

authors： Sedý J,Urdzíková L,Likavcanová K,Hejcl A,Burian M,Jendelová P,Zicha J,Kunes J,Syková E

更新日期：2007-09-01 00:00:00

abstract：:A new experimental model was developed to induce diffuse brain injury (DBI) in rats through pure coronal plane angular acceleration. An impactor was propelled down a guide tube toward the lateral extension of the helmet fixture. Upon impactor-helmet contact, helmet and head were constrained to rotate in the coronal pl...

journal_title：Journal of neurotrauma

authors： Fijalkowski RJ,Stemper BD,Pintar FA,Yoganandan N,Crowe MJ,Gennarelli TA

更新日期：2007-08-01 00:00:00

abstract：:Traumatic brain injury (TBI) is a silent epidemic affecting approximately 1.4 million Americans annually, at an estimated annual cost of $60 billion in the United States alone. Despite an increased understanding of the pathophysiology of closed head injury, there remains no pharmacological intervention proven to impro...

journal_title：Journal of neurotrauma

authors： Laskowitz DT,McKenna SE,Song P,Wang H,Durham L,Yeung N,Christensen D,Vitek MP

更新日期：2007-07-01 00:00:00

abstract：:The presence of pelvic visceral inputs to neurons in the rostral medulla that are responsive to electrical stimulation of the abdominal branches of the vagus nerve (VAG-abd) was investigated in a complete chronic T8 spinal transection rat model. Using extracellular electrophysiological recordings from single medullary...

journal_title：Journal of neurotrauma

authors： Kaddumi EG,Hubscher CH

更新日期：2007-07-01 00:00:00

abstract：:Severe traumatic brain injury (TBI) is one of the major causes of death in younger age groups. In Umeå, Sweden, an intracranial pressure (ICP) targeted therapy protocol, the Lund concept, has been used in treatment of severe TBI since 1994. Decompressive craniectomy is used as a protocol-guided treatment step. The pri...

journal_title：Journal of neurotrauma

authors： Olivecrona M,Rodling-Wahlström M,Naredi S,Koskinen LO

更新日期：2007-06-01 00:00:00

abstract：:Whiplash injury, commonly encountered in road traffic accidents, is a major cause of morbidity. Its pathophysiology is not well understood, and diagnosis remains clinical. Imaging and electrophysiological methods have not provided objective diagnostic evidence. Availability of a sensitive and specific diagnostic metho...

journal_title：Journal of neurotrauma

authors： Lo YL,Tan YE,Fook-Chong S,Boolsambatra P,Yue WM,Chan LL,Tan SB

更新日期：2007-06-01 00:00:00

abstract：:The efficacy of end-to-side repair as a method of nerve reconstruction has been questioned, and most studies that characterize the mode of re-innervation are marred by inappropriate experimental design and lack quantitative analysis. This makes characterization of re-innervating neurons confusing and consequently cont...

journal_title：Journal of neurotrauma

authors： Sananpanich K,Galea MP,Morrison WA,Messina A

更新日期：2007-05-01 00:00:00

abstract：:This study characterized the Infinite Horizon (IH) Impactor for use in mouse models of contusion spinal cord injury (SCI), and investigated the feasibility and reliability of using magnetic resonance imaging (MRI) as a method to accurately measure lesion volume after mouse contusion SCI. Eight-week-old female C57Bl/6 ...

journal_title：Journal of neurotrauma

authors： Nishi RA,Liu H,Chu Y,Hamamura M,Su MY,Nalcioglu O,Anderson AJ

更新日期：2007-04-01 00:00:00

abstract：:To test if observed vs. expected mortality differs by age among traumatic brain injury (TBI) cases, a population-based, historical cohort study was conducted in Olmsted County, Minnesota. From all residents with any diagnosis suggestive of TBI 1985-1999, we randomly sampled 7,800 and reviewed their medical records to ...

journal_title：Journal of neurotrauma

authors： Flaada JT,Leibson CL,Mandrekar JN,Diehl N,Perkins PK,Brown AW,Malec JF

更新日期：2007-03-01 00:00:00

abstract：:Changes in the modes of cerebrovascular pressure transmission during cerebral vasodilation induced by hypercapnic challenge were examined as a means for developing the basis for a bedside method to evaluate regulation of cerebral blood flow. Recordings of arterial blood pressure (ABP) and intracranial pressure (ICP) o...

journal_title：Journal of neurotrauma

authors： Daley ML,Pourcyrous M,Timmons SD,Leffler CW

更新日期：2007-03-01 00:00:00